Author Affiliations: Section of Gastroenterology, Boston University School of Medicine, and Boston Medical Center, Boston, Mass.
Gastrointestinal (GI) toxicity induced by nonsteroidal anti-inflammatory
drugs (NSAIDs) is among the most common serious adverse drug events in the
industrialized world. Gastroduodenal ulcers can be demonstrated by endoscopy
in 10% to 20% of patients who take NSAIDs on a regular basis, and the annual
incidence of clinically important GI complications approaches 2%.1 The impact of NSAIDs on public health is significant
and has provided the impetus to search for safer but equally effective anti-inflammatory
Lichtenstein DR, Wolfe MM. COX-2–Selective NSAIDsNew and Improved?. JAMA. 2000;284(10):1297-1299. doi:10.1001/jama.284.10.1297