Comment & Response
November 12, 2014

Erythropoietin for Traumatic Brain Injury

Author Affiliations
  • 1Department of Critical Care Medicine, University College Dublin, Dublin, Ireland
  • 2Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia
  • 3Department of Intensive Care, Western Health, Victoria, Australia

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JAMA. 2014;312(18):1928-1929. doi:10.1001/jama.2014.12738

To the Editor Dr Robertson and colleagues1 conducted a 2 × 2 factorial design randomized clinical trial of 200 patients with traumatic brain injury to test the effect of 2 approaches to transfusion threshold and erythropoietin therapy on neurological outcome. Unfortunately, their findings that erythropoietin failed to demonstrate an outcome benefit reflect substantial lack of statistical power.

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