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Comment & Response
November 12, 2014

Erythropoietin for Traumatic Brain Injury—Reply

Author Affiliations
  • 1Department of Neurosurgery, Baylor College of Medicine, Houston, Texas
  • 2University of Texas School of Public Health, Houston
JAMA. 2014;312(18):1929. doi:10.1001/jama.2014.12744

In Reply Most of the evidence to date supporting neuroprotection after traumatic brain injury with erythropoietin administration comes from experimental studies. Two case-matched studies in patients with traumatic brain injury and large clinical trials in general trauma patients have found improvements in mortality with erythropoietin treatment.13 For patients with traumatic brain injury, however, recovery of neurological function long-term is more important than simple survival and none of these previous studies have adequately addressed long-term outcome.

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