In Reply Most of the evidence to date supporting neuroprotection after traumatic brain injury with erythropoietin administration comes from experimental studies. Two case-matched studies in patients with traumatic brain injury and large clinical trials in general trauma patients have found improvements in mortality with erythropoietin treatment.1- 3 For patients with traumatic brain injury, however, recovery of neurological function long-term is more important than simple survival and none of these previous studies have adequately addressed long-term outcome.
Robertson CS, Yamal J, Tilley BC. Erythropoietin for Traumatic Brain Injury—Reply. JAMA. 2014;312(18):1929. doi:10.1001/jama.2014.12744