JAMA 100 Years Ago Section Editor: Jennifer
Reiling, Editorial Assistant.
C. C. EASTERBROOK
The origin of organo-therapeutics dates from Brown-Séquard's
experiments in 1889 and the doctrine of internal secretion formulated by him
that "all glands and all tissues have an internal secretion and all injected
subcutaneously have a tonic effect" is taken as the text of this article.
During the past five or six years Easterbrook has administered in various
forms of insanity extracts of the following animal organs: The thyroid gland,
the parathyroid bodies, the thymus, the pituitary body, the brain, the choroid
plexus, the spleen, the suprarenal bodies, the testes, the ovaries, the uterus,
and the mammæ. With the exception of the thyroid, none of these have
been very generally employed by alienists, and parathyroid extract so far
as he knows has not been employed before at all.
ORGANO-THERAPEUTICS IN MENTAL DISEASES.. JAMA. 2000;284(12):1490. doi:10.1001/jama.284.12.1490