Despite numerous studies, how to best manage stable coronary artery disease (CAD)—CAD outside the setting of acute coronary syndrome—remains unknown. Clinical trials of medical treatment, percutaneous coronary intervention (PCI), and coronary artery bypass graft surgery (CABG) have yielded conflicting results. Consequently, how clinicians choose to interpret the literature influences the treatments they use. Because randomized clinical trials (RCTs) are considered the highest level of evidence, many clinicians may assume that recommendations emanating from an RCT should be sufficient to help decide what therapy is best.
Sherwood MW, Peterson ED. Revascularization in Stable Coronary Artery Disease. JAMA. 2014;312(19):2028-2029. doi:10.1001/jama.2014.9314