Author Affiliations: Division of Dermatology, Santa Clara Valley Medical Center, San Jose, Calif (Dr Kanzler) and Department of Dermatology, Stanford University School of Medicine (Drs Kanzler and Mraz-Gernhard), Stanford, Calif.
Contempo Updates Section Editor: Alice T.
D. Hughes, MD, Fishbein Fellow.
With a lack of scientific data, standard of care for treatment of patients
with melanoma at the beginning of the 20th century called for extensive mutilating
surgery and/or local amputation of involved body areas. In the mid-1900s,
aggressive lymph node dissections were popular in an attempt to control metastatic
disease despite the lack of scientific data that such procedures did, indeed,
affect the survival of patients with melanoma. The treatment of melanoma has
changed significantly in the intervening years, and can now be guided by data
regarding clinical outcomes. The purpose of this review is to present clinicians
with an evidence-based summary of the current literature regarding therapy
for primary cutaneous melanoma.
Kanzler MH, Mraz-Gernhard S. Treatment of Primary Cutaneous Melanoma. JAMA. 2001;285(14):1819-1821. doi:10.1001/jama.285.14.1819