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Contempo Updates
April 25, 2001

Nitric Oxide Deficiency as a Cause of Clinical HypertensionPromising New Drug Targets for Refractory Hypertension

Author Affiliations

Author Affiliations: Department of Internal Medicine, Hypertension Division, and the Donald W. Reynolds Cardiovascular Clinical Research Center, University of Texas Southwestern Medical Center, Dallas.


Contempo Updates Section Editors: Stephen J. Lurie, MD, PhD, Senior Editor; Alice T. D. Hughes, MD, Fishbein Fellow.

JAMA. 2001;285(16):2055-2057. doi:10.1001/jama.285.16.2055

The nitric oxide pathway contributes to the blood pressure–lowering effects of many commonly used therapeutic agents and emerging basic research on this pathway is elucidating potential new antihypertensive drug targets. Understanding the regulation of the nitric oxide pathway also provides a conceptual framework for understanding the potential role played by nitric oxide in a number of disorders, including congestive heart failure, atherosclerosis, nitrate tolerance, muscular dystrophy, circulatory shock, and male sexual dysfunction.

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