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Comment & Response
November 26, 2014

Exercise to Combat Depression—Reply

Author Affiliations
  • 1Royal Edinburgh Hospital, Edinburgh, United Kingdom
  • 2Institute of Child Health, University of Liverpool, Liverpool, United Kingdom
  • 3Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom
JAMA. 2014;312(20):2167. doi:10.1001/jama.2014.14340

In Reply The synopsis of our Cochrane review of exercise for depression described the key results, the summary estimates of standardized mean differences, of the larger review. These results underwent rigorous peer review prior to publication in the Cochrane Library. We are confident about the validity and interpretation of the overall effect size, which was moderate and equivalent to a difference in the Beck Depression Inventory (BDI) of about 5 points between exercise and control.

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