Author Affiliations: Department of Psychiatry, Columbia University College of Physicians and Surgeons, and New York State Psychiatric Institute, New York, NY.
Contempo Updates Section Editor: Alice T.
D. Hughes, MD; and Janet M. Torpy, MD, Fishbein Fellows.
Depression occurring in the setting of a nonpsychiatric medical illness
is often considered to be a psychological reaction. Clinicians attribute the
patient's feelings of vulnerability, fear, and diminished self-esteem to the
onset of a severe illness. However, recent data have forced reconsideration
of this belief and new models of the relationship between depression and other
medical illnesses have emerged. Compelling evidence suggests that depression
is an independent risk factor that contributes to the development of ischemic
heart disease (IHD) and increases cardiac mortality. However, abandoning the
concept of depression as a reaction to illness seems premature as the relationship
between depression and other illnesses is complex and may vary. This article
will discuss different models of interaction between depression and other
illnesses using patients with IHD, cerebrovascular disease, and erectile dysfunction
(ED) as illustrations.
Roose SP, Glassman AH, Seidman SN. Relationship Between Depression and Other Medical Illnesses. JAMA. 2001;286(14):1687-1690. doi:10.1001/jama.286.14.1687