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November 7, 2001

Inflammatory Markers in Coronary Artery DiseaseLet Prevention Douse the Flames

Author Affiliations

Author Affiliation: Zena and Michael A. Wiener Cardiovascular Institute, Mount Sinai School of Medicine, New York, NY.

JAMA. 2001;286(17):2154-2156. doi:10.1001/jama.286.17.2154

Atherothrombosis is increasingly recognized as a dynamic chronic inflammatory process of the vessel wall, in which phases of inflammatory and thrombotic activity underlie the clinical presentations of acute coronary syndromes (ACS).1 There is also evolving evidence that circulating monocytes and white blood cells may be involved in a proinflammatory or prothrombotic circulatory state.2,3 These 2 mechanisms—inflammatory involvement of the vessel wall and of the circulating blood—are not mutually exclusive, and both could occur within an individual patient. Two reports in this issue of THE JOURNAL draw attention to the inflammatory basis of coronary atherothrombotic disease.

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