Author Affiliation: Zena and Michael A. Wiener Cardiovascular Institute, Mount Sinai School of Medicine, New York, NY.
Atherothrombosis is increasingly recognized as a dynamic chronic inflammatory
process of the vessel wall, in which phases of inflammatory and thrombotic
activity underlie the clinical presentations of acute coronary syndromes (ACS).1 There is also evolving evidence that circulating monocytes
and white blood cells may be involved in a proinflammatory or prothrombotic
circulatory state.2,3 These 2
mechanisms—inflammatory involvement of the vessel wall and of the circulating
blood—are not mutually exclusive, and both could occur within an individual
patient. Two reports in this issue of THE JOURNAL draw attention to the inflammatory
basis of coronary atherothrombotic disease.
Vorchheimer DA, Fuster V. Inflammatory Markers in Coronary Artery DiseaseLet Prevention Douse the Flames. JAMA. 2001;286(17):2154-2156. doi:10.1001/jama.286.17.2154