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Clinical Crossroads Update
November 28, 2001

A 25-Year-Old Woman With Bipolar Disorder, 1 Year Later

Author Affiliations

From the Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, 330 Brookline Ave, LY318, Boston, MA 02215.

JAMA. 2001;286(20):2594. doi:10.1001/jama.286.20.2594

In April 2000, at Psychiatry Grand Rounds, Gary Sachs, MD, discussed the epidemiology, natural history, diagnosis, and treatment of bipolar disorder.1 Ms G, a 25-year-old woman, exhibited pressured speech, tangential thinking, and labile affect prior to her 2 psychiatric admissions. Due to her concern about weight gain with lithium carbonate, she was treated with divalproex and olanzapine. As an outpatient, Ms G was taking divalproex (750 mg, twice daily) and bupropion hydrochloride (150 mg, twice daily). She recognized the ongoing need for medications, but hoped to get off them over time. She wondered what other treatment modalities might be available to her.

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