Author Affiliation: Center for Human Nutrition, University of Texas Southwestern Medical Center at Dallas.
In this issue of THE JOURNAL, Feskanich and colleagues1
report that women enrolled in the Nurses' Health Study (NHS) who had the highest
intake of vitamin A and, specifically, retinol had higher rates of nontraumatic
hip fracture than women with the lowest intake. This association raises important
questions on the safety of long-term ingestion of dietary retinol. But should
these observations alter recommendations for retinol or provitamin A intake
from foods, fortified foods, and supplements? To answer, the sources and functions
of dietary vitamin A must be considered.
Denke MA. Dietary Retinol—A Double-edged Sword. JAMA. 2002;287(1):102–104. doi:10.1001/jama.287.1.102