Author Affiliations: Division of Preventive Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston Mass.
Despite the common perception that postmenopausal hormone therapy improves
quality of life in women, few randomized clinical trials have addressed this
issue. Moreover, the high rates of discontinuation of hormone therapy in the
first few years of use in both observational studies1,2
and randomized trials3 cast doubt on this assumption.
The study by Hlatky et al4 in this issue of
THE JOURNAL presents important and intriguing data regarding hormone therapy
and quality of life that were previously lacking. This report is particularly
informative because the investigators stratify their results according to
the presence or absence of vasomotor flushing symptoms at baseline.
Rexrode KM, Manson JE. Postmenopausal Hormone Therapy and Quality of LifeNo Cause for Celebration. JAMA. 2002;287(5):641-642. doi:10.1001/jama.287.5.641