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February 13, 2002

Safe Sex for Men With Coronary Artery DiseaseExercise, Sildenafil, and Risk of Cardiac Events

Author Affiliations

Author Affiliation: University of Queensland, Brisbane, Australia.

JAMA. 2002;287(6):766-767. doi:10.1001/jama.287.6.766

Sildenafil has been in widespread use for 3 years, but concerns persist regarding its safety in patients with a history of cardiac disease. Major adverse effects, including myocardial infarction and death, have been recorded in case reports and postmarketing surveillance.1 However, questions have been raised regarding the accuracy of these reports, the potential for reporting bias, and whether the number of reported events exceeds that expected in a population of this age.2 The central issue is to what extent these adverse events reflect a risk from the drug and to what extent they reflect the risks of physical activity in patients with coronary artery disease.

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