Copyright 2002 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2002American Medical Association
The FDA has approved ibritumomab tiuxetan (Zevalin, IDEC Pharmaceutical Corp, San Diego) as part of a two-step regimen for the treatment of patients with relapsed or refractory low-grade, follicular, or transformed B-cell non-Hodgkin lymphoma, including patients with follicular non-Hodgkin lymphom refractory to rituximab (Rituxan, Genentech Inc, San Francisco).
Zevalin is an immunoconjugate that combines the linker-chelator tiuxetan with the monoclonal antibody ibritumomab, directed against the CD (cluster designation)–20 antigen restricted to B lymphocytes. The chelator allows for the antibody to be conjugated to a radioisotope. Step 1 of the regimen includes one infusion of rituximab followed by Indium-111 Zevalin. Step 2, administered 7-9 days later, consists of a second infusion of rituximab followed by Yttrium-90 Zevalin.
Crawford, Jr LM. New Therapy for Non-Hodgkin Lymphoma. JAMA. 2002;287(13):1640. doi:10.1001/jama.287.13.1640