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Special Communication
Clinician's Corner
May 8, 2002

The Glycemic IndexPhysiological Mechanisms Relating to Obesity, Diabetes, and Cardiovascular Disease

Author Affiliations

Author Affiliation: Department of Medicine, Children's Hospital, Boston, Mass.

JAMA. 2002;287(18):2414-2423. doi:10.1001/jama.287.18.2414
Abstract

The glycemic index was proposed in 1981 as an alternative system for classifying carbohydrate-containing food. Since then, several hundred scientific articles and numerous popular diet books have been published on the topic. However, the clinical significance of the glycemic index remains the subject of debate. The purpose of this review is to examine the physiological effects of the glycemic index and the relevance of these effects in preventing and treating obesity, diabetes, and cardiovascular disease.

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