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From the Food and Drug Administration
June 12, 2002

Synthetic Secretin Approved

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JAMA. 2002;287(22):2936. doi:10.1001/jama.287.22.2936

The FDA has approved secretin (SecreFlo, Chesapeake Biological Laboratories, Baltimore), a synthetic formulation of the naturally occurring porcine hormone (no longer available for clinical use) for the following uses: (1) as a diagnostic test of exocrine pancreatic function. Normal response to secretin administration is volume output greater than 2.0 mL/Kg/h, and bicarbonate concentration greater than 80 mmol/L; and (2) as a test to aid in diagnosis of gastrinoma. In the absence of gastrinoma, serum gastrin levels change minimally or not at all in response to secretin.

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