The FDA has approved secretin (SecreFlo, Chesapeake Biological Laboratories, Baltimore), a synthetic formulation of the naturally occurring porcine hormone (no longer available for clinical use) for the following uses: (1) as a diagnostic test of exocrine pancreatic function. Normal response to secretin administration is volume output greater than 2.0 mL/Kg/h, and bicarbonate concentration greater than 80 mmol/L; and (2) as a test to aid in diagnosis of gastrinoma. In the absence of gastrinoma, serum gastrin levels change minimally or not at all in response to secretin.
Crawford, Jr LM. Synthetic Secretin Approved. JAMA. 2002;287(22):2936. doi:10.1001/jama.287.22.2936