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November 13, 2002

Vitamin E and C Supplements and Risk of Dementia

Author Affiliations

Letters Section Editor: Stephen J. Lurie, MD, PhD, Senior Editor.

JAMA. 2002;288(18):2266-2268. doi:10.1001/jama.288.18.2266

To the Editor: Oxidative stress may be involved in the pathogenesis of both Alzheimer disease (AD) and vascular dementia (VaD).1 A controlled trial of vitamin E supplementation among patients with AD found delayed time to institutionalization, but no specific effect on cognitive function.2 Observational studies have found vitamin E and vitamin C to be protective against both AD3,4 and VaD.5