Letters Section Editor: Stephen J. Lurie,
MD, PhD, Senior Editor.
To the Editor: Oxidative stress may be involved
in the pathogenesis of both Alzheimer disease (AD) and vascular dementia (VaD).1 A controlled trial of vitamin E supplementation
among patients with AD found delayed time to institutionalization, but no
specific effect on cognitive function.2 Observational
studies have found vitamin E and vitamin C to be protective against both AD3,4 and VaD.5
Laurin D, Foley DJ, Masaki KH, White LR, Launer LJ. Vitamin E and C Supplements and Risk of Dementia. JAMA. 2002;288(18):2266-2268. doi:10.1001/jama.288.18.2266