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November 13, 2002

Thrombolytic Therapy vs Angioplasty in Acute Myocardial InfarctionThrombolytic Therapy vs Angioplasty in Acute Myocardial Infarction

Author Affiliations

Letters Section Editor: Stephen J. Lurie, MD, PhD, Senior Editor.

JAMA. 2002;288(18):2263-2264. doi:10.1001/jama.288.18.2263

To the Editor: We have several concerns about the study by Dr Aversano and colleagues.1 First, the study was only single-blind. Because of the nature of the randomized groups, follow-up and management of patients with primary PCI could lead to unrecognized bias introduced into the study in the form of preferential management of PCI patients. This potential bias could have been minimized if enrolled patients underwent cardiac angiography and then were randomized to receive thrombolysis and mild catheter manipulation vs PCI and placebo "thrombolysis."

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