Letters Section Editor: Stephen J. Lurie,
MD, PhD, Senior Editor.
In Reply: Dr Varner suggests that the protective
effect of foods rich in vitamin E against AD may reflect activity of γ-
but not α-tocopherol and that this effect is mediated by inhibition
of COX-2 production. We did not investigate these points directly. However,
neither our study nor that of Engelhart et al1 definitely
excluded a supplement effect. Furthermore, animal studies suggest a neuroprotective
effect by α-tocopherol.2 Finally,
other epidemiologic studies have suggested a beneficial effect of supplements,3 and there is no definitive evidence for a protective
effect of NSAIDs against AD.
Morris MC, Evans DA, Bienias JL, Tangney CC, Bennett DA, Aggarwal N, Wilson RS, Scherr PA. Antioxidants and Risk of Alzheimer DiseaseAntioxidants and Risk of Alzheimer Disease. JAMA. 2002;288(18):2265-2266. doi:10.1001/jama.288.18.2265