Letters Section Editor: Stephen J. Lurie,
MD, PhD, Senior Editor.
In Reply: Dr Varner offers an explanation why
antioxidants from food but not from supplements might be related to the risk
of AD. We would like to emphasize that we did not conclude that use of antioxidant
supplements is not associated with lower risk of AD. Rather, we focused on
the relationship between dietary intake and risk of AD. Because only a small
number of participants from our study used supplements, and because we did
not have data on duration and frequency of use, we could not fully explore
the effect of antioxidant supplements.
Engelhart MJ, Breteler MMB. Antioxidants and Risk of Alzheimer DiseaseAntioxidants and Risk of Alzheimer Disease. JAMA. 2002;288(18):2265-2266. doi:10.1001/jama.288.18.2265