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November 13, 2002

Antioxidants and Risk of Alzheimer DiseaseAntioxidants and Risk of Alzheimer Disease

Author Affiliations

Letters Section Editor: Stephen J. Lurie, MD, PhD, Senior Editor.

JAMA. 2002;288(18):2265-2266. doi:10.1001/jama.288.18.2265

In Reply: Dr Varner offers an explanation why antioxidants from food but not from supplements might be related to the risk of AD. We would like to emphasize that we did not conclude that use of antioxidant supplements is not associated with lower risk of AD. Rather, we focused on the relationship between dietary intake and risk of AD. Because only a small number of participants from our study used supplements, and because we did not have data on duration and frequency of use, we could not fully explore the effect of antioxidant supplements.