Stephen J.LurieMD, PhD, Senior Editor
To the Editor: Dr Glassman and colleagues1 found that sertraline treatment was not associated with significant changes in left ventricular ejection fraction (LVEF) or in electrocardiographic or Holter recording parameters among patients with acute myocardial infarction (MI) or unstable angina. Although there was a lower rate of cardiac hospitalizations in patients treated with sertraline vs placebo, the trend was nonsignificant. Thus, sertraline may produce an increase, a decrease, or no difference in cardiac hospitalization rates. A larger trial, with more meaningful end points, is necessary to assess the safety of this intervention.
Lespérance F, Frasure-Smith N. Sertraline for Treatment of Depression in Acute Coronary Syndromes. JAMA. 2002;288(19):2403. doi:10.1001/jama.288.19.2403