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November 27, 2002

Estrogen Replacement Therapy and Risk of Ovarian Cancer in Postmenopausal Women

Author Affiliations

Stephen J.LurieMD, PhD, Senior Editor


Not Available


Copyright 2002 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2002American Medical Association

JAMA. 2002;288(20):2538. doi:10.1001/jama.288.20.2538

To the Editor: Dr Lacey and colleagues1 reported an increased risk of ovarian cancer in women who used unopposed estrogen, but not among women who used an estrogen-progestin combination. However, the histology of these tumors was described for only one third of the cases. A significant difference was found only for endometrioid cancers. Another study had similar findings, with only a significant increase in endometrioid and clear cell epithelial cancers among women receiving unopposed estrogen.2 In that study, the risk was greater in women who had received a tubal ligation or a hysterectomy, thus suggesting a possible role of estrogen-stimulating endometriosis.

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