[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Citations 0
The World in Medicine
December 11, 2002

Genetic Clues Shed Light on Stomach Cancer Risk

Author Affiliations

Not Available

Not Available

JAMA. 2002;288(22):2813. doi:10.1001/jama.288.22.2813

Although people infected with Helicobacter pylori have an increased risk of stomach cancer, only some develop the malignancy. Now, new findings by researchers at the University of Porto, in Portugal, and colleagues indicate that stomach cancer risk can be substantially increased when people with specific gene variants, or polymorphisms, are infected with certain strains of H pylori (J Natl Cancer Inst. 2002;94:1680-1687).

In the study of 221 people with chronic gastritis and 222 people with stomach cancer, the investigators analyzed H pylori DNA (from patient specimens) for genetic variations in two virulence-associated genes. They also analyzed each patient's DNA for genetic variations in two genes: the gene that encodes interleukin 1β, and the gene for interleukin 1 receptor antagonist. Certain versions of these genes can lead to severe and chronic gastric inflammation, decreased acid secretion, and gastric atrophy, ultimately resulting in development of stomach cancer.

First Page Preview View Large
First page PDF preview
First page PDF preview