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January 1, 2003

Corticosteroids for Patients With Septic Shock

JAMA. 2003;289(1):41-44. doi:10.1001/jama.289.1.41-a

To the Editor: Dr Annane and colleagues1 claim that corticotropin nonresponders with septic shock who were treated with corticosteroids had a significantly decreased mortality. This claim is based on an adjusted Cox model that corrects for baseline cortisol, cortisol response to tetracosactin, McCabe classification, Logistic Organ Dysfunction score, arterial lactate concentration, and PAO2/Fio2. The authors were able to show a modest decrease in mortality only after correcting for these factors.

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