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January 8, 2003

Vitamin Supplementation in Elderly Persons

Author Affiliations

Letters Section Editor: Stephen J. Lurie, MD, PhD, Senior Editor.

JAMA. 2003;289(2):173. doi:10.1001/jama.289.2.173-a

In Reply: We agree with Dr Chandra and with Dr Girodon and colleagues that the composition of the multivitamin-mineral supplement may have contributed to our null findings. We chose to use a commercially available supplement with only the micronutrients reported to be relevant to the immune response, and which are often suboptimal in the elderly population. For minerals, we included 50% of the RDA for elderly persons because of safety reasons: therapeutic and toxic levels of some minerals, such as copper, zinc, and iron, are reported to be close to one another.1

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