Washington—As the microscope gained favor
in the mid-17th century, Dutch naturalist Antonie van Leeuwenhoek peered into
the world of bacteria and blood cells. "I then most always saw, with great
wonder," he wrote of a bit of plaque scraped from his teeth, "that in the
said matter there were many very little living animalcules, very prettily
a-moving." Three and a half centuries later, confocal microscopes bring to
the viewer three-dimensional images of a cell's most intricate structures.
Vastag B. Gene Chips Inch Toward the Clinic. JAMA. 2003;289(2):155-159. doi:10.1001/jama.289.2.155