February 5, 2003

Prevention of Contrast Nephropathy

Author Affiliations

Author Affiliations: Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass.

JAMA. 2003;289(5):606-608. doi:10.1001/jama.289.5.606

Contrast nephropathy is one of the well-recognized risks of coronary angiography. Although the disease occurs infrequently with normal renal function, its frequency increases with decreasing renal function, ranging from 5% in patients with mild renal insufficiency1 to 50% in those with severe renal dysfunction and diabetes.2 Given that contrast nephropathy is associated with increased morbidity, mortality, and length of hospitalization, and possibly with long-term renal impairment,3 there is great interest in its prevention.

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