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February 5, 2003

Ginkgo and Memory

JAMA. 2003;289(5):546. doi:10.1001/jama.289.5.546-a

To the Editor: Dr Solomon and colleagues1 reported that 6 weeks of treatment with Ginkgo biloba failed to improve performance on standardized neuropsychological tests of learning, memory, attention, and verbal ability in healthy elderly adults without cognitive impairment. The authors argue that clinical findings to date have not supported claims that ginkgo improves cognitive efficiency. Their study, however, is not directly comparable with prior studies, which have varied significantly in terms of trial durations, predictor and outcome measures used, and the type of cohort tested. Moreover, the authors do not mention several methodologically comparable studies,2,3 including our 1-month trial,4 which have reported selective improvements in neuropsychological status in young adults and healthy older subjects treated with ginkgo.

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