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February 5, 2003

Ginkgo and MemoryGinkgo and Memory

JAMA. 2003;289(5):546. doi:10.1001/jama.289.5.546-a

To the Editor: I have several concerns about the study by Dr Solomon and colleagues.1 First, it may be inappropriate for the randomization to be performed by the lead investigator and not by an independent person. Second, the authors state that their placebo was "lactose gelatin capsules of similar appearance." The active pill, however, is a film-coated tablet; it is virtually inconceivable that a gelatin capsule could be sufficiently similar in shape and surface to effectively maintain double-blind conditions. Furthermore, the same persons who provided the pills to the study participants also conducted the neuropsychological evaluations, which may have further compromised the blinding.

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