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February 5, 2003

Ginkgo and MemoryGinkgo and Memory

JAMA. 2003;289(5):546. doi:10.1001/jama.289.5.546-a

To the Editor: Dr Solomon and colleagues1 state that the cognitive effect size for ginkgo in dementia is significantly smaller than that of cholinesterase inhibitors. Effect sizes for cholinesterase inhibitors in mild to moderate Alzheimer disease have tended to be larger than those seen with other classes of agents.2,3 However, to our knowledge, there are no adequately powered published trials that have directly compared a cholinesterase inhibitor with ginkgo for dementia. Indirect comparisons of effect sizes across dementia trials must be interpreted with caution because the rate of cognitive decline varies significantly by type of dementia, baseline dementia severity, trial duration, and dose of agents being studied.2,3

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