Letters Section Editor: Stephen J. Lurie,
MD, PhD, Senior Editor.
To the Editor: Dr Kjeldsen and colleagues1 reported that among elderly individuals with isolated
systolic hypertension (ISH), those treated with losartan had a nearly 50%
reduction in the risk of stroke compared with those treated with atenolol.
In contrast to previous results,2 the effect
appeared to be independent of degree of blood pressure control. There was
no difference in the incidence of cardiac events, suggesting that this effect
may have been mediated by the differing brain selectivities of the 2 drugs.
Fournier A, Oprisiu R, Andrejak M, Fernandez L, Achard JM. Losartan vs Atenolol in Prevention of Stroke and Cardiovascular Disease. JAMA. 2003;289(6):700-701. doi:10.1001/jama.289.6.700-a