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Health Agencies Update
February 19, 2003

From Blood Cells to Neurons

JAMA. 2003;289(7):833. doi:10.1001/jama.289.7.833-a

A study of brain tissue from patients who died after bone marrow transplants has provided convincing evidence that blood stem cells can migrate to the brain and blossom into clumps of active gray and white matter, report researchers from the National Institute of Neurological Disorders and Stroke (NINDS) and the Johns Hopkins Medical Institutions.

Previous experiments had shown that 1% to 2% of all neurons in mice that had received bone marrow transplants were derived from blood stem cells. "I thought this was all well and good for mousekind, but what about people?" said Éva Mezey, MD, PhD, a neuroanatomist at the NINDS.

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