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February 26, 2003

Idiopathic vs Hereditary Pancreatitis

Author Affiliations

Letters Section Editor: Stephen J. Lurie, MD, PhD, Senior Editor.

JAMA. 2003;289(8):983-985. doi:10.1001/jama.289.8.983a

To the Editor: In their Research Letter, Dr Simon and colleagues reported a high percentage of trypsinogen mutations in patients with nonalcoholic (idiopathic) chronic pancreatitis.1 However, the authors do not cite a number of previous studies of this relationship, some of which found a weaker association.26 The 5 largest studies of the association of chronic idiopathic pancreatitis and trypsinogen mutations are shown in Table 1. We focused on the most common trypsinogen mutations, A16V, N29I, and R122H, as they were the only ones clearly shown to be disease associated.

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