Letters Section Editor: Stephen J. Lurie,
MD, PhD, Senior Editor.
To the Editor: Dr Simon and colleagues report
that the hereditary pancreatitis–associated cationic trypsinogen (PRSS1) gene mutation, R122H, was present in 5 (10%) of
50 patients with idiopathic pancreatitis.1 We
have a number of concerns about this report.
First, they did not reference 3 closely related studies.2- 4 In
particular, 1 study evaluated the known hereditary pancreatitis–associated PRSS1 gene mutations in a large cohort of patients with
Chen J, Férec C. Idiopathic vs Hereditary PancreatitisIdiopathic vs Hereditary Pancreatitis. JAMA. 2003;289(8):983-985. doi:10.1001/jama.289.8.983a