Letters Section Editor: Stephen J. Lurie,
MD, PhD, Senior Editor.
In Reply: In response to Drs Keim and Teich,
we suggest that publication or rejection of trials in top medical journals
may be more related to quality than publication bias against negative studies.1 A number of published studies (21 to our knowledge)
have reported alterations in established disease genes from various subgroups
of patients with pancreatitis. Unfortunately, few investigators have applied
the stringent criteria for idiopathic pancreatitis used in our study, and
none have investigated the extended families of patients with seemingly sporadic
trypsinogen mutations. Because this was the specific focus of our study, and
because of the limit for references in our Research Letter, we restricted
citations to the most relevant work for our report.
Weiss FU, Simon P, Hohoff C, Zimmer KP, Domschke W, Lerch MM. Negative-Pressure Ventilation. JAMA. 2003;289(8):983-985. doi:10.1001/jama.289.8.983a