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February 26, 2003

Idiopathic vs Hereditary Pancreatitis

Author Affiliations

Letters Section Editor: Stephen J. Lurie, MD, PhD, Senior Editor.

JAMA. 2003;289(8):985-987. doi:10.1001/jama.289.8.985a

In Reply: In response to Drs García and Tenias, we agree that observational studies pose a greater risk for bias and confounding than do well-conducted randomized clinical trials. While we sought to identify randomized clinical trials on this topic, we could find only observational studies. Nonetheless, observational studies can help to inform clinical practice, and methods to minimize bias when conducting systematic reviews of observational studies are well accepted.1 We used these methods (the MOOSE recommendations) in the conduct of our systematic review and included a detailed discussion of the potential biases of our review.

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