Letters Section Editor: Stephen J. Lurie,
MD, PhD, Senior Editor.
In Reply: In response to Drs García
and Tenias, we agree that observational studies pose a greater risk for bias
and confounding than do well-conducted randomized clinical trials. While we
sought to identify randomized clinical trials on this topic, we could find
only observational studies. Nonetheless, observational studies can help to
inform clinical practice, and methods to minimize bias when conducting systematic
reviews of observational studies are well accepted.1 We
used these methods (the MOOSE recommendations) in the conduct of our systematic
review and included a detailed discussion of the potential biases of our review.
Pronovost PJ, Angus DC. Idiopathic vs Hereditary Pancreatitis. JAMA. 2003;289(8):985-987. doi:10.1001/jama.289.8.985a