Washington—The Web site advertisement
would pique the interest of just about any man. As an animated gas gauge needle
drops, questions appear. "Fatigued?" asks the ad. "Depressed mood? Low sex
drive? Could be your testosterone is running on empty!"
The ad is from Unimed Pharmaceuticals Inc, the Marietta, Ga, marketer
of a testosterone gel whose sales quadrupled to $144 million worldwide in
Approved by the US Food and Drug Administration (FDA) for hypogonadism,
or clinically low testosterone in otherwise healthy men, testosterone replacement
products are arousing concern from researchers who question a lack of data
on long-term safety. So much so, in fact, that the Institute of Medicine (IOM)
has been called on to help design large-scale studies.
Vastag B. Many Questions, Few Answers for Testosterone Replacement Therapy. JAMA. 2003;289(8):971-972. doi:10.1001/jama.289.8.971