Letters Section Editor: Stephen J. Lurie,
MD, PhD, Senior Editor.
To the Editor: Dr Zandi and colleagues1 found that HRT nonusers were significantly older
than HRT users and had a 300% higher incidence of AD. Women with missing data
on HRT use were even older than nonusers and had an additional 250% higher
incidence of AD. Thus, it appears that these age differences were responsible
for most of the increased incidence of AD. It is possible that at least some
of the older women did not recall their HRT use simply because they were at
the early stages of AD.
Lahad A, Ishay L. Estrogen Replacement and Risk of Alzheimer DiseaseEstrogen Replacement and Risk of Alzheimer Disease. JAMA. 2003;289(9):1100-1102. doi:10.1001/jama.289.9.1100-a