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March 5, 2003

Estrogen Replacement and Risk of Alzheimer DiseaseEstrogen Replacement and Risk of Alzheimer Disease

Author Affiliations

Letters Section Editor: Stephen J. Lurie, MD, PhD, Senior Editor.

JAMA. 2003;289(9):1100-1102. doi:10.1001/jama.289.9.1100-a

To the Editor: Dr Zandi and colleagues1 found that HRT nonusers were significantly older than HRT users and had a 300% higher incidence of AD. Women with missing data on HRT use were even older than nonusers and had an additional 250% higher incidence of AD. Thus, it appears that these age differences were responsible for most of the increased incidence of AD. It is possible that at least some of the older women did not recall their HRT use simply because they were at the early stages of AD.

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