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March 5, 2003

Estrogen Replacement and Risk of Alzheimer DiseaseEstrogen Replacement and Risk of Alzheimer Disease

Author Affiliations

Letters Section Editor: Stephen J. Lurie, MD, PhD, Senior Editor.

JAMA. 2003;289(9):1100-1102. doi:10.1001/jama.289.9.1100-a

To the Editor: Dr Zandi and colleagues1 argue that underreporting of HRT use among women who subsequently develop AD is unlikely because of the "notable nature of a decision to use HRT and the tendency of women to use HRT for an extended period of time." Furthermore, the authors note no relationships between "control exposures" (ie, calcium and multivitamins) and the incidence of AD. The authors conclude it is unlikely that women who later developed dementia would have selectively forgotten making a "carefully considered decision to use HRT."

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