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March 5, 2003

Estrogen Replacement and Risk of Alzheimer Disease

Author Affiliations

Letters Section Editor: Stephen J. Lurie, MD, PhD, Senior Editor.

JAMA. 2003;289(9):1100-1102. doi:10.1001/jama.289.9.1100-a

In Reply: We agree with Dr Smith and colleagues that there are a variety of direct and indirect mechanisms by which estrogen and estrogen-containing hormone therapy could affect brain function or be associated with neurologic disease. The pathogenic relevance of modest elevations in plasma gonadotropin concentrations observed in women (but not men) with AD1 is open to speculation and, of course, to experimental investigation and empirical validation.

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