Letters Section Editor: Stephen J. Lurie,
MD, PhD, Senior Editor.
In Reply: We agree with Dr Smith and colleagues
that there are a variety of direct and indirect mechanisms by which estrogen
and estrogen-containing hormone therapy could affect brain function or be
associated with neurologic disease. The pathogenic relevance of modest elevations
in plasma gonadotropin concentrations observed in women (but not men) with
AD1 is open to speculation and, of course,
to experimental investigation and empirical validation.
Resnick SM, Henderson VW. Estrogen Replacement and Risk of Alzheimer Disease. JAMA. 2003;289(9):1100-1102. doi:10.1001/jama.289.9.1100-a