Letters Section Editor: Stephen J. Lurie,
MD, PhD, Senior Editor.
To the Editor: Drs Hu and Willett1 state
that "in 1908, Ignatowski produced atherosclerosis in rabbits with a diet
high in cholesterol and saturated fat." Ignatowski is credited with having
suggested that there could be a possible connection between foods rich in
cholesterol and experimental atherosclerosis. But the credit for having produced
atherosclerosis in rabbits in 1913 by feeding them a cholesterol-rich diet
goes to Anichkov and Chalatov.2 Their results
were not accepted universally as being relevant to human disease since cholesterol
is not a normal constituent of the rabbit's diet.
Siew S. Optimal Diets to Prevent Heart DiseaseOptimal Diets to Prevent Heart Disease. JAMA. 2003;289(12):1509-1511. doi:10.1001/jama.289.12.1509-a