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March 26, 2003

Optimal Diets to Prevent Heart DiseaseOptimal Diets to Prevent Heart Disease

Author Affiliations

Letters Section Editor: Stephen J. Lurie, MD, PhD, Senior Editor.

JAMA. 2003;289(12):1509-1511. doi:10.1001/jama.289.12.1509-a

To the Editor: Drs Hu and Willett1 state that "in 1908, Ignatowski produced atherosclerosis in rabbits with a diet high in cholesterol and saturated fat." Ignatowski is credited with having suggested that there could be a possible connection between foods rich in cholesterol and experimental atherosclerosis. But the credit for having produced atherosclerosis in rabbits in 1913 by feeding them a cholesterol-rich diet goes to Anichkov and Chalatov.2 Their results were not accepted universally as being relevant to human disease since cholesterol is not a normal constituent of the rabbit's diet.

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