[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 54.163.147.69. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Citations 0
Letters
April 9, 2003

Animal Models of Human Diabetic Polyneuropathy

Author Affiliations
 

Letters Section Editor: Stephen J. Lurie, MD, PhD, Senior Editor.

JAMA. 2003;289(14):1779-1780. doi:10.1001/jama.289.14.1779-a

To the Editor: Drs Sheetz and King1 stated that "[a]nimal models of diabetes support the importance of hyperglycemia as a causative factor in diabetic neuropathy. . . . " However, models in which the animal is made hyperglycemic do not reproduce the essential neuropathologic features of human diabetic neuropathy, especially the loss of unmyelinated C fibers.2 It is damage to fibers mediating pain that is responsible for trophic ulcers, damage to metatarsal heads, and Charcot joints.

First Page Preview View Large
First page PDF preview
First page PDF preview
×