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April 9, 2003

Animal Models of Human Diabetic Polyneuropathy

Author Affiliations

Letters Section Editor: Stephen J. Lurie, MD, PhD, Senior Editor.

JAMA. 2003;289(14):1779-1780. doi:10.1001/jama.289.14.1779-a

To the Editor: Drs Sheetz and King1 stated that "[a]nimal models of diabetes support the importance of hyperglycemia as a causative factor in diabetic neuropathy. . . . " However, models in which the animal is made hyperglycemic do not reproduce the essential neuropathologic features of human diabetic neuropathy, especially the loss of unmyelinated C fibers.2 It is damage to fibers mediating pain that is responsible for trophic ulcers, damage to metatarsal heads, and Charcot joints.

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