Letters Section Editor: Stephen J. Lurie,
MD, PhD, Senior Editor.
To the Editor: Drs Sheetz and King1 stated that "[a]nimal models of diabetes support
the importance of hyperglycemia as a causative factor in diabetic neuropathy.
. . . " However, models in which the animal is made hyperglycemic do not reproduce
the essential neuropathologic features of human diabetic neuropathy, especially
the loss of unmyelinated C fibers.2 It is
damage to fibers mediating pain that is responsible for trophic ulcers, damage
to metatarsal heads, and Charcot joints.
Crawford CL, Hardwicke P. Animal Models of Human Diabetic Polyneuropathy. JAMA. 2003;289(14):1779-1780. doi:10.1001/jama.289.14.1779-a