Letters Section Editor: Stephen J. Lurie,
MD, PhD, Senior Editor.
To the Editor: Davì et al1 recently
reported that android obesity is associated with enhanced lipid peroxidation
and persistent platelet activation, both of which can be reduced by weight
loss. In this context, enhanced circulating soluble CD40 ligand (CD40L) has
recently been suggested to be associated with platelet activation.2- 4 CD40L is a
trimeric, transmembrane protein of the tumor necrosis factor family that is
cryptic in unstimulated platelets but is rapidly expressed on the platelet
surface after platelet stimulation.3 Thus,
increased levels of circulating soluble CD40L represent an index of platelet
activation.2- 4 We
assessed the relationship between central obesity and levels of circulating
soluble CD40L and the effect of weight loss on this measure of platelet activation.
Desideri G, Ferri C. Effects of Obesity and Weight Loss on Soluble CD40L Levels. JAMA. 2003;289(14):1781-1782. doi:10.1001/jama.289.14.1781