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April 9, 2003

Effects of Obesity and Weight Loss on Soluble CD40L Levels

Author Affiliations

Letters Section Editor: Stephen J. Lurie, MD, PhD, Senior Editor.

JAMA. 2003;289(14):1781-1782. doi:10.1001/jama.289.14.1781

To the Editor: Davì et al1 recently reported that android obesity is associated with enhanced lipid peroxidation and persistent platelet activation, both of which can be reduced by weight loss. In this context, enhanced circulating soluble CD40 ligand (CD40L) has recently been suggested to be associated with platelet activation.24 CD40L is a trimeric, transmembrane protein of the tumor necrosis factor family that is cryptic in unstimulated platelets but is rapidly expressed on the platelet surface after platelet stimulation.3 Thus, increased levels of circulating soluble CD40L represent an index of platelet activation.24 We assessed the relationship between central obesity and levels of circulating soluble CD40L and the effect of weight loss on this measure of platelet activation.

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