[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 54.205.176.107. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Citations 0
The World in Medicine
April 9, 2003

"Atypical" Pneumonia Alert

JAMA. 2003;289(14):1774. doi:10.1001/jama.289.14.1774-a

Researchers from the University of Brussels, Gosselies, Belgium and colleagues have discovered a strategy that Trypanosoma brucei rhodesiense, the parasite that causes sleeping sickness, uses to overcome natural human defenses against infection (Nature. 2003;222:83-87).

Human serum contains a molecule called trypanosome lytic factor that can prevent infection. Some strains of the parasite make a shortened version of a cell surface molecule called serum resistance-associated protein (SRA) that allows them to evade this defense, but the identity of the lytic factor and the exact molecular mechanism of this evasion were unknown.

First Page Preview View Large
First page PDF preview
First page PDF preview
×