Letters Section Editor: Stephen J. Lurie,
MD, PhD, Senior Editor.
To the Editor: Dr Steinhubl and colleagues1 evaluated the effects of long-term treatment with
clopidogrel and the benefit of a preprocedural loading dose in patients undergoing
percutaneous coronary intervention (PCI). They reported that patients had
better 1-year outcomes if they were treated with clopidogrel in addition to
aspirin. I have several concerns about their study.
Choudhury RP. Clopidogrel and Percutaneous Coronary Interventions—Reply. JAMA. 2003;289(15):1925-1927. doi:10.1001/jama.289.15.1925-a