Letters Section Editor: Stephen J. Lurie,
MD, PhD, Senior Editor.
To the Editor: Despite of the absence of benefit
associated with clopidogrel pretreatment at 28 days, Dr Steinhubl and colleagues1 drew attention to a trend in favor of benefit among
those who received clopidogrel loading 6 to 24 hours prior to PCI. Patients
who received clopidogrel pretreatment within 6 hours prior to PCI did not
experience any benefit. While it is biologically plausible that a longer pretreatment
interval might be necessary, this observation would be rendered more credible
if a relationship could be demonstrated between pretreatment interval and
magnitude of benefit. Although such a supplementary analysis might be underpowered,
the results may be informative nonetheless.
Wong BYL, Cohen EA. Clopidogrel and Percutaneous Coronary Interventions. JAMA. 2003;289(15):1925-1927. doi:10.1001/jama.289.15.1925-a