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April 23/30, 2003

Long-term Cardiovascular Consequences of Diuretics vs Calcium Channel Blockers vs Angiotensin-Converting Enzyme Inhibitors

JAMA. 2003;289(16):2066. doi:10.1001/jama.289.16.2066-a

To the Editor: The authors of The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT)1 reported that lisinopril, amlodipine, and chlorthalidone were associated with similar 5-year risks of cardiac death or nonfatal myocardial infarction among patients with hypertension. However, chlorthalidone was more effective than lisinopril or amlodipine in preventing the development of heart failure. Chlorthalidone was also more effective than lisinopril in preventing combined coronary vascular disease (CVD) and stroke.

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