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Letters
May 14, 2003

Cholinesterase Inhibitors for Alzheimer DiseaseCholinesterase Inhibitors for Alzheimer Disease

Author Affiliations
 

Letters Section Editor: Stephen J. Lurie, MD, PhD, Senior Editor.

JAMA. 2003;289(18):2359. doi:10.1001/jama.289.18.2359-a

To the Editor: Dr Trinh and colleagues1 concluded that ChIs have a "modest beneficial impact on neuropsychiatric and functional outcomes for patients with AD." The differences, in fact, were exceedingly small.

The most important point of view, though, is that of the caregivers. It would be of interest to know if there were data about whether they thought that these drugs provided benefit to their loved ones, or whether they themselves had any improvement in their quality of life. If not, then I would interpret these results as clinically insignificant.

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