Letters Section Editor: Stephen J. Lurie,
MD, PhD, Senior Editor.
To the Editor: Strenuous physical exercise,
when performed to the point of exhaustion, can generate free radicals that
can cause muscle damage.1 We have previously
reported that xanthine oxidase, a free radical–generating enzyme involved
in the ischemia-reperfusion syndrome, may cause damage associated with exhaustive
exercise.2 In this study, we tested whether
allopurinol (a xanthine oxidase inhibitor) would affect markers of muscle
damage among participants in a strenuous sporting event.
Gómez-Cabrera M, Pallardó FV, Sastre J, Viña J, García-del-Moral L. Allopurinol and Markers of Muscle Damage Among Participants in the Tour de France. JAMA. 2003;289(19):2503-2504. doi:10.1001/jama.289.19.2503-b