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May 21, 2003

Allopurinol and Markers of Muscle Damage Among Participants in the Tour de France

Author Affiliations

Letters Section Editor: Stephen J. Lurie, MD, PhD, Senior Editor.

JAMA. 2003;289(19):2503-2504. doi:10.1001/jama.289.19.2503-b

To the Editor: Strenuous physical exercise, when performed to the point of exhaustion, can generate free radicals that can cause muscle damage.1 We have previously reported that xanthine oxidase, a free radical–generating enzyme involved in the ischemia-reperfusion syndrome, may cause damage associated with exhaustive exercise.2 In this study, we tested whether allopurinol (a xanthine oxidase inhibitor) would affect markers of muscle damage among participants in a strenuous sporting event.

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